Internet-delivered CBT for Anxiety Related to Asthma

Karolinska Institute

Status: Active, not recruiting

Conditions: Asthma; Anxiety

Treatments: Other: Treatment as usual; Behavioral: Exposure-based Internet-CBT

Study type: Interventional

Funder types: Other

Identifiers

NCT04230369

MANTRA03

Details and patient eligibility

About

This is a randomized controlled trial to investigate efficacy of a internet-delivered CBT for anxiety related to asthma.

Full description

Asthma is one of the most common chronic diseases and is often associated with anxiety. In a two prior studies (ClinicalTrials.gov ID: NCT03158194; NCT03486756) a protocol for exposure-based cognitive behaviour therapy (CBT) for anxiety related to asthma was developed, and standardised to an internet-delivered format and tested for feasibility and acceptability as an internet-CBT. The aim of the current study is to evaluate the efficacy of exposure-based Internet-CBT for anxiety related to asthma compared to Treatment as Usual (TAU). The plan is to include 90 participants consecutively during 2020.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• asthma diagnosed by a physician
• worry about asthma or limitations in daily life due to asthma at

Exclusion criteria

• a serious psychiatric condition; e.g., suicidality, psychosis or severe substance addiction
• chronic obstructive pulmonary disease (COPD) or other chronic airway disorders other than asthma

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

90 participants in 2 patient groups

Internet-CBT

Experimental group

Description:

The internet-CBT will comprise 8 weekly modules with therapist-support, encouraging exposure for fear of asthma symptoms while ensuring a stable asthma medication through a written medical plan on medical adherence Participants work independently from home with the treatment and receive weekly support from their psychologist through written messages online.

Treatment:

Behavioral: Exposure-based Internet-CBT

Treatment as usual

Other group

Description:

Patients randomized to treatment as usual will receive the same medical information that participants in the Internet-CBT get, with physiological information about asthma and the importance of medical adherence to achieve well controlled asthma, but without the exposure-based treatment and no therapist support. All participants in both conditions can use any other available treatment, but psychological, from pre-assessments to 2 months after treatment completion. Participants in this arm will be crossed over to Internet-CBT after the primary endpoint at to 2 months follow up.

Treatment:

Other: Treatment as usual