Internetbased Relapse Prevention for Partially Remitted Depression (ISAK)

Örebro County Council

Status: Unknown

Conditions: Depression

Treatments: Behavioral: iCBT

Study type: Interventional

Funder types: Other

Identifiers

NCT01807988

2012/488

Details and patient eligibility

About

The main purpose of the study is to test whether Internet-based relapse prevention plus medication has a better protective effect compared to medication only, for persons with residual depressive symptoms who are currently in paid employment or in education. We hypothesise that during the two years following the intervention:

• The persons in the group receiving Internet-based relapse prevention plus medication will be absent from work for fewer days due to sick-leave compared to those in the medication-only group.
• Fewer persons in the group receiving Internet-based relapse prevention + medication will experience long term sick-leave (60 days or more) compared to those in the medication-only group.
• The persons in the group receiving Internet-based relapse prevention plus medication will suffer fewer depressive relapses compared to those in the medication-only group.
• At follow-up, the persons in the group receiving Internet-based relapse prevention plus medication will have higher health related quality of life and lower levels of depressive symptoms compared to those in the medication-only group.

Enrollment: 264 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mild residual depressive symptoms (7-19 on the MADRS-S).
• A history of at least one episode of Major Depression.
• Currently in (at least) half-time employment, self-employment or education.
• Taking a stable (since one month) and therapeutic dosage of antidepressant medication
• Being able to read and write Swedish
• Having access to the internet

Exclusion criteria

• Fulfilling the criteria for Major depression
• Psychosis
• Substance abuse
• Suicidality

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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264 participants in 2 patient groups

iCBT

Experimental group

Description:

Internetbased cognitive behavior therapy (iCBT) aimed att preventing relapse into major depression.

Treatment:

Behavioral: iCBT

Control group

No Intervention group

Description:

The control group in the study will fill out questionnaires every month and will be interviewed every month to detect any relapses. They will also receive feedback on there self-reported symptoms.