Interstitial Lung Disease in Early Rheumatoid Arthritis (ILD-Early RA)

National Jewish Health

Status: Unknown

Conditions: Interstitial Lung Disease; Rheumatoid Arthritis

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03977415

HS-3140

Details and patient eligibility

About

The purpose of this study is to determine how interstitial lung disease can be predicted over time in early rheumatoid arthritis. The investigators will study blood and phlegm samples from participants, along with quality of life questionnaires to determine if and how the presence of ILD may impact the participants quality of life over time.

Full description

Participation involves 5 study visits over an 18 month timeframe. During each of these visits, a recent medical history and physical exam will take place, blood and phlegm will be collected, quality of life questionnaires will be administered, and a CT-scan of the chest and pulmonary function testing may be performed.

Enrollment: 76 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 18 - 90 years
2. Diagnosis of "early RA" with or without ILD as defined by ACR/EULAR 2010 criteria and confirmed by a member of the ILD or Rheumatology programs at National Jewish Health (NJH)
3. Able to read, speak, and understand English
4. Able and willing to perform all study related tasks, including returning to NJH every 6 months for an 18 month period of time

Exclusion criteria

1. Subjects who do not meet all inclusion criteria
2. Pregnant women

Trial design

76 participants in 2 patient groups

RA with no ILD

Description:

Subjects diagnosed with RA less then 2 years and without a diagnosis of ILD, will complete 5 in-person study visits. Visits will be performed every 6 months for 18 months. Study Assessments Include: 1. Medical history and Physical exams 2. Quality of Life Questionnaires 3. Collection of Sputum and Blood 4. Radiology (HRCT) 5. Lung Function Test

RA with ILD

Description:

Patients diagnosed with RA less than 2 years, and clinically diagnosed with interstitial lung disease (ILD), will complete 5 in-person study visits. Visits will be performed every 6 months for 18 months. Study Assessments Include: 1. Medical history and Physical exams 2. Quality of Life Questionnaires 3. Collection of Sputum and Blood 4. Radiology (HRCT) 5. Lung Function Test 6. Spirometry