Intertransverse Process Block for Quality of Recovery Post-Open Hepatectomy (ITPB QoR)

The Chinese University of Hong Kong

Status: Not yet enrolling

Conditions: Quality of Recovery (QoR-15); Intertransverse Process Block; Hepatectomy

Treatments: Procedure: Intertransverse process block

Study type: Interventional

Funder types: Other

Identifiers

NCT06957041

CRE Ref. No. 2024.562

Details and patient eligibility

About

The study aims to assess the analgesic efficacy of the ITPB at the retro-SCTL space in patients undergoing major open hepatectomy surgery. This is assessed by:

Primary Objective:

Primary outcome measure:

● Assessing the quality of recovery 15 (QoR15) score at 24 and 48 hours

Secondary outcome measure:

• Number of anaesthetic and hypoesthetic dermatomes on the ventral and dorsal aspect of the thorax on both the sides at 30 minutes of block completion and during the post anaesthetic room (PACU) discharge
• Assessing the 24-hour area under the curve of postoperative pain numerical rating score (NRS, 0-10) at rest and deep breathing or upon use of triflow.
• Assessing the amount of postoperative morphine (mg) equivalent consumption at 24 and 48 hours
• Time to discharge from High dependency unit (HDU) or Intensive care unit (ICU)

Hypothesis:

The investigators hypothesize that the application of ITPB targeting the retro-SCTL space in patients undergoing open hepatectomy will improve overall quality of recovery and pain score.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients aged 18-75 years of ASA I - III physical status classification undergoing open hepatectomy for benign or malignant liver lesion.

Exclusion criteria

• Patient refusal
• Patients who are unable to comprehend the QoR15 form
• Local or systemic infection
• Coagulopathy leading to absolute contraindication to regional anesthesia
• Contraindication to local anaesthetics (LA) such as LA allergy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Open Hepatectomy Patient receiving the intertransverse process block

Experimental group

Treatment:

Procedure: Intertransverse process block