Interval Inspiratory Training and Aerobic Exercise for Muscle Recovery in Myasthenia Gravis Post-Hospitalization

Chang Gung University

Status: Completed

Conditions: Myasthenia Gravis

Treatments: Procedure: Control Group; Procedure: Inspiratory muscle training

Study type: Interventional

Funder types: Other

Identifiers

NCT06624345

202002115A3

Details and patient eligibility

About

The goal of this clinical trial is to determine whether inspiratory muscle training aids in the recovery of respiratory muscle strength and helps prevent further muscle weakness in patients with myasthenia gravis.

The primary research questions are:

Does inspiratory muscle training enhance respiratory muscle strength recovery? Does the intervention lead to improved lung volumes? Participants underwent daily inspiratory muscle training and aerobic exercise for six consecutive weeks.

Full description

Patients with myasthenia gravis who experience acute exacerbations requiring hospitalization often suffer a significant decline in muscle strength, followed by partial recovery after the acute phase. This randomized controlled trial aims to evaluate the potential of early inspiratory muscle training and aerobic exercise in promoting muscle strength recovery and preventing further weakness. The study will assess differences in lung function, respiratory muscle strength, and dyspnea levels following the intervention after patients are discharged from the hospital post-acute exacerbation.

Enrollment: 68 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalized due to a myasthenia gravis crisis
• Cleared for discharge from the hospital
• Capable of completing six weeks of home-based respiratory muscle and exercise training

Exclusion criteria

• Myasthenia Gravis Foundation of America (MGFA) classification I or V
• Presence of concurrent heart, kidney, liver, or metabolic diseases, or malignant tumors
• Ability to follow exercise instructions
• New York Heart Association (NYHA) Class III/IV
• Pulmonary disease (FEV1/FVC ratio < 0.7 and FEV1 < 50% predicted)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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68 participants in 2 patient groups

Inspiratory Muscle Training

Experimental group

Description:

Subjects participated in a combination of inspiratory muscle training and aerobic exercise for approximately 30 minutes per day over a period of six weeks.

Treatment:

Procedure: Inspiratory muscle training

Control group

Sham Comparator group

Description:

Subjects received routine care.

Treatment:

Procedure: Control Group