Interval-training and Appetite Regulation in Patients With Type 2 Diabetes
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About
Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear.
This study will assess if IW leads to greater exercise-induced suppression of appetite and ad libitum food intake compared to CW and no exercise.
Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
- One hour of rest (CON)
- One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW)
- One hour of continuous walking (CW) matched to IW with regards to energy-expenditure.
After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal), with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin, Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised ad-libitum meal test will be served and intake will recorded. Free-living energy intake via food records will be assessed during the following 32 hours.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Type 2 Diabetes Mellitus
- BMI > 25
Exclusion criteria
- Pregnancy
- Smoking
- Contraindication to increased levels of physical activity
- Eating disorder
- Insulin dependence
Trial design
Primary purpose
Allocation
Interventional model
Masking
14 participants in 3 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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