Interval Training and Plasma Volume Variation

Wissal Abassi

Status: Completed

Conditions: Hematologic Tests

Treatments: Behavioral: Moderate-intensity interval walking training; Behavioral: High intensity interval walking training

Study type: Interventional

Funder types: Other

Identifiers

NCT07019285

Hematological markers

Details and patient eligibility

About

The goal of this clinical trial is to to compare the effects of high (HIIWT) versus moderate-intensity interval walking training (MIIWT) on body composition, plasma volume variations (PVV), hematological parameters, muscle damage and aerobic capacity in overweight/obese postmenopausal women. The main question it aims to answer is:Does HIIWT and MIIWT improve kidney function markers in this population? Researchers will compare HIIWT to MIIWT and to non-training intervention(designed to control group) to see if the training program at different intensities work to improve kidney function markers.

Participants in HIIWT group will: perform a 8-week HIIWT program, three sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 90-110% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in MIIWT group will: perform a 8-week MIIWT program, three sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.

Full description

In obese postmenopausal women, hematological disturbances, reduced plasma volume, and elevated muscle damage biomarkers are associated with impaired oxygen delivery, reduced aerobic capacity, and increased risks of cardiovascular disease, sarcopenia, and functional decline. While responses to exercise are well documented in young healthy individuals, evidence in this high-risk population remains scarce. The purpose is to compare the effects of high (HIIWT) versus moderate-intensity interval walking training (MIIWT) on body composition, plasma volume variations (PVV), hematological parameters, muscle damage and aerobic capacity in overweight/obese postmenopausal women.Thirty-two overweight/obese postmenopausal women were randomly assigned to HIIWT (n = 11), MIIWT (n = 11), or control (CON, n = 10) groups. HIIWT and MIIWT groups performed intermittent walking at 90-110% and 60-80% of the 6-min-walking-test distance, respectively, 3 times/week for 8 weeks (60 min/session). Body composition, hematological and muscle damage markers, and 6 min walk test (6MWT) were assessed pre- and post-intervention. PVV was calculated after eight weeks under third conditions (HIIWT, MIIWT and CON).

Enrollment: 32 patients

Sex: Female

Ages: 45 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age range of 45-59 years.
• Postmenopausal women (cessation of menses for at least 12 consecutive months).
• Body mass index (BMI) ≥ 25 kg/m2.
• Body weight remained constant (±2 kg) during the past 3 months.
• Stable eating habits and physical activity for at least 3 months.
• Sedentary lifestyle (exercise less than 1h/week).

Exclusion criteria

• Medical contraindications to physical activity, diagnosed metabolic, hormonal, orthopedic, or cardiovascular conditions.
• Current use of hormone replacement therapy or any prescribed medication.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 3 patient groups

High-intensity intermittent walking training group

Experimental group

Description:

performed five 6-minute walking bouts at 90-110% of the 6-minute walking test distance (6MWTD) with 6-min of active recovery between repetitions

Treatment:

Behavioral: High intensity interval walking training

Moderate-intensity intermittent walking training group

Experimental group

Description:

repeated five 6-minute walking intervals at 60-80% of 6MWTD interspersed with 6 minutes of active recovery between repetition

Treatment:

Behavioral: Moderate-intensity interval walking training

Control group

No Intervention group

Description:

No training intervention was intended for the control group.