Interval-training in Type 2 Diabetics

Rigshospitalet

Status: Completed

Conditions: Diabetes Mellitus, Type 2

Treatments: Behavioral: Control; Behavioral: Interval walking; Behavioral: Continuous walking

Study type: Interventional

Funder types: Other

Identifiers

NCT02320526

H-6-2014-043

Details and patient eligibility

About

Interval training is superior to continuous training for improving glycemic control, hereunder glycemic variability and -spikes. However, the underlying mechanisms and the clinical impact is at present unknown.

The overall objective of this project is to determine the mechanisms underlying aeroic interval-training-induced reductions in glycemic variability and -spikes, and the impact on levels of systemic inflammation in type 2 diabetes patients. It is hypothesized that aerobic interval training reduces glycemic variability and -spikes more than continuous training due to larger improvements in both peripheral insulin sensitivity and the mass action effect of glucose. Moreover, it is hypothesized that these reductions in glycemic variability and -spikes also reduces systemic inflammation.

Enrollment: 14 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes mellitus
• BMI >18 but <40 kg/m2

Exclusion criteria

• Pregnancy
• Smoking
• Contraindication to increased levels of physical activity
• More than moderate levels of physical activity (>90 min/week) of maximally moderate intensity
• Insulin dependence
• Thyroid, liver, lung, heart or kidney disease, with the need for treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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14 participants in 3 patient groups

Control

Experimental group

Description:

Control intervention: Subjects will continue their life unaltered during the 14 days intervention period

Treatment:

Behavioral: Control

Continuous walking

Experimental group

Description:

Training intervention: Subjects will perform continuous walking for one hour per day at every weekday during the 14 days intervention period

Treatment:

Behavioral: Continuous walking

Interval Walking

Experimental group

Description:

Training intervention: Subjects will perform interval walking for one hour per day at every weekday during the 14 days intervention period. Interval walking will be performed as repeated cycles of three minutes of slow and hree minutes of fast walking during the entire training session

Treatment:

Behavioral: Interval walking