Intervention for Communication Quality of Life in Primary Progressive Aphasia (Multi-PA)

The University of Texas System (UT)

Status: Enrolling

Conditions: Logopenic Variant Primary Progressive Aphasia; Nonfluent Progressive Aphasia; Progressive Aphasia; Nonfluent Variant Primary Progressive Aphasia (nfvPPA); Nonfluent Aphasia, Progressive; Logopenic Progressive Aphasia (LPA); Semantic Variant Primary Progressive Aphasia (svPPA); Logopenic Progressive Aphasia; Logopenic Variant of Primary Progressive Aphasia (LPA); Semantic Dementia; Semantic Aphasia; Primary Progressive Aphasia(PPA)

Treatments: Behavioral: Multicomponent Video Implemented Script Training in Aphasia; Behavioral: Multicomponent Lexical Retrieval Training

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07219680

R61AG089318 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The goal of this clinical trial is to determine whether individually tailored speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language. The study will be offered to individuals who speak English and/or Spanish. The study will also document how acceptable and beneficial the program is to both patients and their care partners.

The main questions the study aims to answer are:

1. Is the telerehabilitation program feasible and acceptable for people with PPA and their care partners?
2. Do participants with PPA and care partners find treatment beneficial?
3. Which outcome measures are most useful for evaluating changes in communication and quality of life?
4. What patterns of treatment response are seen in participants after completing the program?

The program includes both speech-language therapy and training for care partners.

Participants with PPA will:

1. Complete virtual communication tasks and questionnaires before and after the program
2. Take part in online speech-language therapy sessions
3. Include their care partners in some parts of the program for training and support

Enrollment: 25 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for Persons with PPA:

• A PPA (Gorno-Tempini et al., 2011) or "PPA-plus" (Mesulam et al., 2001) diagnosis
• MMSE score of > 15 and must be able to produce single monosyllabic words intelligibly.
• Must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
• Hearing and vision adequate for participation in teleconference meetings
• Must have a care partner available (someone who will commit to attending teleconference sessions weekly during treatment phases)

Inclusion criteria for Care Partners:

• Partners must express willingness to attend and participate in treatment sessions including those targeting dyadic communication goals
• Partners must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
• Partner's hearing and vision should be adequate for participation in teleconference meetings

Exclusion criteria for persons with PPA:

• Other central nervous system or medical diagnosis that can account for symptoms
• Psychiatric diagnosis that can account for symptoms
• The participant and/or study partner must have basic experience using a computer.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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25 participants in 2 patient groups

Waitlist Control

Other group

Description:

Individuals in the waitlist-control group will undergo initial assessment followed by a waiting interval of 10 (Multi-VISTA) or 12 (Multi-LRT) weeks. Following the waiting period, they will again complete baseline assessments prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRT treatment).

Treatment:

Behavioral: Multicomponent Lexical Retrieval Training

Behavioral: Multicomponent Video Implemented Script Training in Aphasia

Immediate Treatment

Experimental group

Description:

Individuals in the immediate treatment group will undergo initial assessment followed immediately by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRT treatment).

Treatment:

Behavioral: Multicomponent Lexical Retrieval Training

Behavioral: Multicomponent Video Implemented Script Training in Aphasia