Intervention in Single Thyroid Nodule.

Assiut University

Status: Not yet enrolling

Conditions: Thyroid Nodule

Treatments: Procedure: thyroidectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT05658809

THYSINGLE

Details and patient eligibility

About

Thyroid nodules are common clinical problem. The incidence is 2-4 per 100,000 people per year, being more common in women and the elderly. thyroid nodule is a "discrete lesion within the thyroid gland that is radiologically distinct from the surrounding thyroid parenchyma. Most thyroid nodules are asymptomatic, may present as neck swelling

Full description

Thyroid nodular disease comprises of a wide range of disorders. Benign forms such as colloid nodules,cysts and thyroiditis are more comman than benign follicular neoplasms and thyroid carcinomas. Incidence of malignancy ranges from 10% to 30% in solitary thyroid nodule(STN).Studies have shown that the occurrence of malignancy is higher in case of solitary thyroid nodule compared to multinodular goitres. Preoperative evaluation of thyroid nodules is important in distinguishing between benign and malignant thyroid nodules and also in treatment to avoid unnecessary extensive surgery and its complications. Fine needle aspiration biopsy (FNAB) is the most common method of examining solitary thyroid nodules today.Total thyroidectomy and lobectomy remain the main primary surgical interventions for single thyroid nodule. There is debat between total thyroidectomy and hemithyroidectomy for patients with single thyroid nodule. our study is for comparing between total thyroidectomy and hemi thyroidectomy in single thyroid nodule

Enrollment: 40 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age from 20 to 60 years.
2. patients with single thyroid lesion
3. Fit for surgery

Exclusion criteria

1. patients with age less than 20 years and more than 60 years.
2. patients with multiple thyroid lesions.
3. patients with advanced and metastatic malignancy.
4. Unfit for surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Total thyroidectomy for single thyroid nodule

Active Comparator group

Description:

group of participants will be treated with total thyroidectomy

Treatment:

Procedure: thyroidectomy

Hemithyroidectomy for single thyroid nodule

Active Comparator group

Description:

2nd group of participants will be treated with hemithyroidectomy

Treatment:

Procedure: thyroidectomy