Intervention Strategy in Chronic Obstructive Pulmonary Disease With Anxiety and Depression

Chinese Academy of Medical Sciences, Fuwai Hospital

Status: Unknown

Conditions: Depression; COPD; Anxiety

Treatments: Behavioral: Pulmonary Rehabilitation Therapy; Behavioral: Cognitive Behavioral Therapy; Behavioral: Combined Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03187249

2016YFC1304404B

Details and patient eligibility

About

Anxiety and depression have negative effect on outcomes of chronic obstructive pulmonary disease (COPD). Intervention strategy including behavioral-cognitive therapy and pulmonary rehabilitation are promising in improving life quality, disease symptom and outcomes. But there's not standard algorithm in China so far. The study aims to compare the effectiveness of these interventions and develop an intervention algorithm of anxiety and depression in COPD.

Enrollment: 500 estimated patients

Sex: All

Ages: Under 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable COPD patients with mild or moderate anxiety and depression

Exclusion criteria

• Patients with bronchial asthma or other severe pulmonary diseases or having received pulmonary surgery in 6 months
• Patients with tumor history during past 5 years
• Patients with COPD exacerbations during past 4 weeks
• Participants in clinical trials
• Patients in pregnancy or breastfeeding
• Patients unable to complete questionaire independently
• Patients older than 80 years old
• Patients receiving long-term domiciliary oxygen therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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500 participants in 4 patient groups

Cognitive Behavioral Therapy

Experimental group

Description:

receive cognitive-behavioral therapy for 12 weeks

Treatment:

Behavioral: Cognitive Behavioral Therapy

Pulmonary Rehabilitation Therapy

Experimental group

Description:

receive pulmonary rehabilitation therapy for 12 weeks

Treatment:

Behavioral: Pulmonary Rehabilitation Therapy

Combined Therapy

Experimental group

Description:

receive both cognitive-behavioral therapy and pulmonary rehabilitation therapy for 12 weeks

Treatment:

Behavioral: Combined Therapy

Regular Therapy

No Intervention group

Description:

receive regular therapy for chronic obstructive pulmonary disease