Intervention Study on the Health Impact of Air Filters in Chinese Adults

Fudan University

Status: Completed

Conditions: Pulmonary Function; Inflammation; Coagulation; Blood Pressure

Treatments: Behavioral: Air purifiers

Study type: Interventional

Funder types: Other

Identifiers

NCT02239744

FDUEH-1

Details and patient eligibility

About

This study aimed to evaluate whether a short-term indoor air purifier intervention improves cardiopulmonary health based on a randomized double-blind crossover trial

Full description

We conducted a randomized double-blind crossover trial among 35 healthy college students in Shanghai, China in 2014. These students lived in dormitories that were randomized into two groups and alternated the use of true or sham air purifiers for 48 hours with a 2-week wash-out interval.All participants and research staff were blinded to the group assignment. We requested all participants to stay in their dormitory room with the windows/doors closed throughout each 48-hour intervention period. We delivered foods and drinks to each room during the intervention period. All interventions started at 8 a.m. to avoid issues related to diurnal variation. We evaluated health endpoints and drew blood immediately after the completion of each 48-hour intervention. We measured 14 circulating biomarkers of inflammation, coagulation and vasoconstriction, lung function, blood pressure (BP), and fractional exhaled nitric oxide (FeNO).

Enrollment: 35 patients

Sex: All

Ages: 18 to 26 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy college students aged between 18 and 26
• All the subjects should stay indoor almost the entire time, and stayed within the central urban area of shanghai during the wash-out period.

Exclusion criteria

• current smokers or ever smokers
• chronic respiratory diseases
• chronic cardiovascular diseases
• acute infections
• medication use in recent one month

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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35 participants in 2 patient groups

True air purification

Experimental group

Description:

One group of subjects used an intervention of true air purifiers placed in the center of the room.

Treatment:

Behavioral: Air purifiers

Sham air purification

Sham Comparator group

Description:

This group of subjects used an intervention of sham air purifiers under the same conditions with true purifiers with the only difference being removal of the filter gauze in the sham purifiers.

Treatment:

Behavioral: Air purifiers