Intervention Targeting Medication Adherence and Methamphetamine Use in HIV Positive Men (ACE)

Hunter College of City University of New York

Status: Completed

Conditions: HIV Medication Adherence; Poly-substance Use; Methamphetamine Use; HIV Infections; Sexual Risk

Treatments: Behavioral: Education Attention Control; Behavioral: Motivational Interviewing + Cognitive Behavioral Skills Training

Study type: Interventional

Funder types: Other

Identifiers

NCT01122186

1R01DA023395

Details and patient eligibility

About

The primary aim is to test an innovative 8-session intervention, based on Motivational Interviewing and Cognitive Behavioral Skills-Training for the co-occurrence of methamphetamine use and highly active antiretroviral therapy (HAART) non-adherence among methamphetamine using HIV+ MSM in NYC, compared to an 8-session educational (ED) condition. Participants in the intervention condition will report greater reductions in the number of days of methamphetamine use and viral load, and greater increases in CD4 counts and self-reported and objectively measured adherence than those in the education condition.

Enrollment: 210 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HIV+ (confirmed at baseline through documentation)
• Biologically male
• report sex with another man at least once
• report methamphetamine use at least three times in the past three months
• report less than 90% HAART medication adherence, as measured by the total number of days a participant missed an HIV medication in the last 30
• able to communicate with staff and complete a survey that is in English.

Exclusion criteria

• Unstable, serious psychiatric symptoms
• Currently suicidal/homicidal
• Evidence of gross cognitive impairment
• Self-reported current enrollment in a drug or HIV-related intervention or research study.
• Methadone use

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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210 participants in 2 patient groups

Intervention Condition

Experimental group

Description:

Eight sessions of Motivational Interviewing and Cognitive Behavioral Skills Training, adapted to target both MA use and medication adherence, as well as sexual risk behaviors and polydrug use.

Treatment:

Behavioral: Motivational Interviewing + Cognitive Behavioral Skills Training

Education Condition

Active Comparator group

Description:

Eight sessions of education with content designed to mirror the information covered in the intervention condition. The content will be as follows: 3 sessions focusing on medication adherence; 3 sessions focusing on the dangers of methamphetamine use; 1 session addressing sexual risk; and 1 session addressing poly-substance use.

Treatment:

Behavioral: Education Attention Control