Interventional Bronchoscopy Under Noninvasive Ventilation

Futian People's Hospital

Status: Unknown

Conditions: Noninvasive Positive Pressure Ventilation;; Bronchoscopy；; Interventional；; Sedation;; Central Airway Stenosis

Treatments: Procedure: invasive ventilation; Drug: general anesthesia(midazolam, fentanyl，rocuronium，propofol and Remifentanil）; Device: noninvasive ventilation; Procedure: interventional bronchoscopy; Drug: sedation(dezocine and midazolam)

Study type: Interventional

Funder types: Other

Identifiers

NCT02289586

szkcw-2014-322

Details and patient eligibility

About

To evaluate the effect and safety of noninvasive ventilation assisted interventional bronchoscopy for hypoxemia patients with central airway stenosis.

With the sedation and analgesia, noninvasive ventilation assisted interventional bronchoscopy for hypoxemia patients with central airway stenosis is safe and effective, carries high satisfaction rate.

Enrollment: 40 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• (a)patients with central airway stenosis need interventional bronchoscopy. (b) partial pressure of arterial oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio less than 300;

Exclusion criteria

• (a) facial deformity sufficient to preclude mask fitting; (b) upper gastrointestinal bleeding; (c) upper airway obstruction; (d) acute coronary syndromes; (e) tracheostomy or endotracheal intubation(ETI) before admission; (f) need for urgent ETI due to cardiac or respiratory arrest.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

hypoxemia, central airway stenosis.

Active Comparator group

Description:

Inclusion Criteria: * (a)patients with central airway stenosis need interventional bronchoscopy (b) partial pressure of arterial oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio less than 300; Exclusion Criteria: * (a) facial deformity sufficient to preclude mask fitting; (b) upper gastrointestinal bleeding; (c) upper airway obstruction; (d) acute coronary syndromes; (e) tracheostomy or endotracheal intubation(ETI) before admission; (f) need for urgent ETI due to cardiac or respiratory arrest.

Treatment:

Procedure: interventional bronchoscopy

Procedure: invasive ventilation

Drug: general anesthesia(midazolam, fentanyl，rocuronium，propofol and Remifentanil）

hypoxemia, central airway stenosis

Experimental group

Description:

Inclusion Criteria: * (a)patients with central airway stenosis need interventional bronchoscopy (b) partial pressure of arterial oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio less than 300; Exclusion Criteria: * (a) facial deformity sufficient to preclude mask fitting; (b) upper gastrointestinal bleeding; (c) upper airway obstruction; (d) acute coronary syndromes; (e) tracheostomy or endotracheal intubation(ETI) before admission; (f) need for urgent ETI due to cardiac or respiratory arrest.

Treatment:

Procedure: interventional bronchoscopy

Device: noninvasive ventilation

Drug: sedation(dezocine and midazolam)