Interventions for Postoperative Delirium: Biomarker-3 (IPOD-B3)

University of Wisconsin (UW)

Status

Enrolling

Conditions

Delirium

Treatments

Procedure: High Density-Electroencephalogram

Diagnostic Test: Pupillometry

Procedure: Blood specimen collection

Procedure: Magnetic Resonance Imaging

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT03124303

1R01AG063849-01 (U.S. NIH Grant/Contract)

1K23AG055700-01A1 (U.S. NIH Grant/Contract)

Protocol Version 1/15/25 (Other Identifier)

A530900 (Other Identifier)

SMPH\ANESTHESIOLOGY (Other Identifier)

2015-0374

Details and patient eligibility

About

The IPOD-B3 study aims to characterize the relationship between premorbid brain activity and postoperative delirium in patients undergoing major surgery. This is a expansion of the NeuroVISION Bolt-On study, NCT01980511.

Enrollment

468 estimated patients

Sex

All

Ages

60+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Cohort 1: Age ≥65 years
Cohort 2: Age ≥60 years
Anticipated length of hospital stay of at least 2 days after surgery that occurs under general or neuraxial anesthesia
Written Informed Consent for potential participation prior to surgery

Exclusion criteria

Contraindication to EEG
Unable or unwilling to attend the follow-up appointments
Documented history of dementia
Deemed incapable of providing consent by surgical team
Residing in a nursing home
Undergoing intracranial surgery
Unable to complete neurocognitive testing due to language, vision or hearing impairment
Unable to communicate with the research staff due to language barriers
For optional MRI portion of the study: Contraindication to MRI (e.g., implanted devices not safe for MRI studies, claustrophobia, unable to lie flat or still)