Interventions to Improve HIV Antiretroviral Therapy Adherence

University of Michigan

Status: Completed

Conditions: Human Immunodeficiency Virus (HIV) Infection

Treatments: Behavioral: Information; Behavioral: Financial Incentive; Behavioral: Information and Stigma-relieving; Behavioral: Financial Incentive and Reminders; Behavioral: Reminders; Behavioral: Stigma-relieving

Study type: Interventional

Funder types: Other

Identifiers

NCT03618511

HUM00133179

Details and patient eligibility

About

This study will explore whether financial incentives, reminders, information about HIV/AIDS and its treatment and anti-stigma counseling help improve anti-retroviral therapy (ART) adherence among HIV infected individuals in a resource-limited environment. The interventions will be randomized in the study population in a cross-cutting design, with a control group, a financial incentive treatment group, a reminders treatment group, a treatment group that receives both the financial incentive and reminder interventions. In addition, there will be an information treatment group, a stigma-relieving treatment group and a group that receives both information and stigma-relieving interventions. The primary outcomes of interest for this study will be the adherence to ART, measured by attendance rates at clinic appointments and refill collection rates.

Enrollment: 914 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infected with HIV;
• Have not start ART, or started ART less than 90 days before;
• Have a phone number on which can discuss private health matters.

Exclusion criteria

• Not infected with HIV;
• On ART for more than 90 days;
• Do not have a private phone.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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914 participants in 7 patient groups

Financial Incentive Group

Experimental group

Treatment:

Behavioral: Financial Incentive

Reminders Group

Experimental group

Treatment:

Behavioral: Reminders

Financial Incentive and Reminders Group

Experimental group

Treatment:

Behavioral: Financial Incentive and Reminders

Control Group

No Intervention group

Information Group

Experimental group

Treatment:

Behavioral: Information

Stigma-relieving Group

Experimental group

Treatment:

Behavioral: Stigma-relieving

Information and Stigma-relieving Group

Experimental group

Treatment:

Behavioral: Information and Stigma-relieving