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Objective: What precipitates ocular inflammatory episodes remains unknown, but a possible potentiating factor is the microbiome. The microbiome has become increasingly studied with the advent of new techniques, but these have not been applied to uveitis. We wish to evaluate microbiome composition in patients with the ocular inflammatory diseases uveitis who may be on standard therapy or receiving orally-administered tolerizing antigen therapy.
Study Population: A total of 200 participants may be enrolled in this study. Of those participants, the goal is to enroll 50 healthy controls and 150 with various types of uveitis.
Design: This is an observational, prospective, single-center study. Participants will receive a complete ocular examination with clinical testing as determined clinically and will provide stool and blood samples using a standardized method. Participants may have multiple visits and may provide multiple samples in order to evaluate changes in microbiota composition with disease status or treatment.
Outcome Measures: Alterations in bacterial diversity, microbiota composition and changes in relative abundance of various taxa or species will be analyzed between healthy volunteers and participants and between various types of uveitis. In addition, comparisons will be made between these findings and the immunome and metabolome.
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Inclusion and exclusion criteria
Inclusion Criteria for Uveitis Participants
Participant must be 18 years of age or older.
Participant must have a diagnosis of:
Uveitis (or ocular inflammatory disorder)
Participant must be able to undergo slit lamp biomicroscopy.
Participant must understand and sign the protocol s informed consent document.
Inclusion Criteria for Healthy Volunteers
EXCLUSION CRITERIA:
Exclusion Criteria for Uveitis Participants
Exclusion Criteria for Healthy Volunteers
131 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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