Intestinal Failure in Necrotising Enterocolitis
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About
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disorder with high morbidity and mortality (20-40%), affecting predominantly premature neonates. NEC continues to present a diagnostic challenge to clinicians. The initial clinical manifestations of NEC are non-specific and indistinguishable from other gastrointestinal disorders and sepsis.
The first goal of this study is to find and evaluate tests to diagnose NEC at an early stage. For the development of new diagnostic markers, the investigators require knowledge of pathophysiological processes that underlie NEC, which still remain unclear. Therefore, the second goal of this study is to elucidate the etiology of NEC. Furthermore, understanding of the pathophysiology of NEC can offer the possibility to develop new therapeutical treatments.
Enrollment
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Volunteers
Inclusion criteria
- Neonates with abdominal signs suspected of NEC
- All neonates admitted to the NICU of the Maastricht University Medical Center between July 2007 and July 2008
Exclusion criteria
- No written informed consent of both parents
Trial design
300 participants in 3 patient groups
Trial contacts and locations
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Central trial contact
Kostan Reisinger, MD
Data sourced from clinicaltrials.gov
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