Intestinal Microbial Dysbiosis in Chinese Infants With Short Bowel Syndrome With Different Complications (MSBS)

Shanghai Jiao Tong University

Status

Completed

Conditions

Short Bowel Syndrome

Complications

Treatments

Other: Complications

Study type

Observational

Funder types

Other

Identifiers

NCT02699320

XH-16-001

Details and patient eligibility

About

There are no reports involved the intestinal microbiota from Chinese infants with short bowel syndrome (SBS) under different clinical status. Alterations in the microbiota are closely correlated with the bile acids and short chain fatty acids metabolism as well as the intestinal immunity. A relatively comprehensive profile composed of microbial structure, microbial metabolism products and immune biomarkers in SBS infants may facilitate a better therapy strategy to complications occurred in SBS children.

Full description

The investigators totally collected 26 fecal samples from 18 infants diagnosed with SBS during parenteral nutrition administration, and these samples were divided into three groups according to complications of enrolled patients at sampling time: asymptomatic group, central catheter-related blood stream infections group and liver injury group. 7 healthy infants with supplementary food were enrolled as control. Fecal microbiota, sIgA and calprotectin, bile acids and short chain fatty acids were also detected by 16S ribosomal ribonucleic acid (rRNA) gene sequencing, enzyme-linked immunosorbent assay and liquid/gas chromatography.

Enrollment

33 patients

Sex

All

Ages

Under 1 year old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Infants with short bowel syndrome

Trial design

33 participants in 4 patient groups

"Asymptomatic"

Description:

"Asymptomatic" meaning patients showed well tolerance to parenteral nutrient (PN) administration and there were no complications occurred within two months (n=7);

Treatment:

Other: Complications

CLABSI

Description:

with central catheter-related blood stream infections (CLABSI) meaning patients had fever, increased neutrophils, documented positive catheter blood culture but exclude other source of infection (n=5)

Treatment:

Other: Complications

PNALD

Description:

with parenteral nutrient associated liver disease (PNALD), meaning SBS patients showed elevated liver enzymes and bilirubin (n=14).

Treatment:

Other: Complications

healthy controls

Description:

Seven healthy infants who had added complementary were served as controls (n=7).

Treatment:

Other: Complications