Intestinal Microbiota and Antimicrobial Resistance in Hong Kong Residents After Travel

The Chinese University of Hong Kong

Status: Completed

Conditions: Antimicrobial Resistance

Study type: Observational

Funder types: Other

Identifiers

NCT03794479

travellers_version 2_20180724

Details and patient eligibility

About

International travel is well reported to be associated with acquisition of multidrug-resistant organisms, however, the impact of colonization of these multidrug-resistant organisms is currently uncertain. As colonization of multidrug-resistant organisms had been demonstrated to be associated with distinct intestinal microbiota composition and travellers constitute a generally healthy population with minimal antibiotics exposure; by evaluating serial stool samples before and after travel, the investigators can delineate a potential causal relationship between host intestinal microbiota and subsequent risk of acquisition of multidrug-resistant organisms.

Enrollment: 125 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 18 years or above
• Chinese ethnicity
• Planning to visit any places outside of Hong Kong within the next three months
• Able to provide informed consent

Exclusion criteria

• Use of antibiotics within 4 weeks prior to the time of recruitment (Except for antimalarial prophylaxis)
• Hospitalization within 3 months
• Underlying gastrointestinal diseases, including gastrointestinal malignancy, inflammatory bowel disease, resection of small or large bowel
• Pregnancy

Trial design

125 participants in 1 patient group

Travellers

Description:

Adults planning for travel