Intestinal Microbiota and Postoperative Ileus After Colorectal Surgery (MICRO-IPO)

University Hospital, Angers

Status: Completed

Conditions: Surgery-Complications; Postoperative Ileus

Treatments: Other: Feces collection

Study type: Observational

Funder types: Other

Identifiers

NCT05512741

MicroIPO2022

Details and patient eligibility

About

Postoperative ileus (POI) after colorectal surgery is frequent and is a burden for national health authority because it increases the morbidity and the length of hospital stay.

Some of the stage of the mechanism of POI are known and are now targeted to reduce its occurence but despite these measures, POI still happens in 10-30% of surgeries.

The role of the intestinal microbiota in POI is unknown while it could be a new target to reduce its duration or its occurence.

Enrollment: 64 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• laparoscopic colorectal resection with anastomosis and without diverting stoma

Exclusion criteria

• risk of modification of the microbiota (terminal enterostomy, chronic inflammatory bowel disease, oesophageal or gastric surgery, vagal nerves lesion, beta lactamin allergy, bowel cleansing)
• postoperative complication

Trial design

64 participants in 2 patient groups

Group Ileus

Description:

Patients that experience POI after colorectal surgery. POI is defined by the presence of 2 of the 5 criteria of Vather from the first postoperative day. The first 10 consecutive patients experiencing POI will be included in the study.

Treatment:

Other: Feces collection

No POI group

Description:

Patients that do not experience POI. The 10 patients having the fastest recovery of gastro-intestinal functions after surgery during the period of inclusion will be included in the study

Treatment:

Other: Feces collection