Intra-Abdominal Instillation Of Fresh Frozen Plasma Versus Corticosteroids In Prevention Of Recurrent Attacks Of Adhesive Intestinal Obstruction: A 2 Years' Experience Clinical Study

Zagazig University

Status: Active, not recruiting

Conditions: Adhesive Peritoneal Band

Treatments: Procedure: intra-abdominal instillation of fresh frozen plasma; Procedure: intra-abdominal instillation of corticosteroids

Study type: Interventional

Funder types: Other

Identifiers

NCT06859307

#1109\25-Feb-2025

Details and patient eligibility

About

Adhesive Intestinal obstruction is an inevitable complication of abdominal surgery with significant morbidity associated with poor quality of life and predispose to repeated hospitalization. Most of them (73% - 90%) can be managed conservatively.Despite advances in surgery, 15to 30% require surgical intervention primarily or due to failure of conservative management. Because of the nature of the disease recurrence has been estimated to be 30%.Many attempts to prevent formation of postoperative adhesions have been tried. In this trial, we will study the effect of corticosteroids and FFP in prevention of adhesive small bowel obstruction recurrence for follow up of 2 years duration.

Enrollment: 176 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with attacks of adhesive intestinal obstruction

Exclusion criteria

• Associated abdominal malignancy, patients with adhesive IO who respond to conservative treatment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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176 participants in 2 patient groups

group I: adhesive intestinal obstruction

Active Comparator group

Treatment:

Procedure: intra-abdominal instillation of corticosteroids

group II: adhesive intestinal obstruction

Active Comparator group

Treatment:

Procedure: intra-abdominal instillation of fresh frozen plasma