Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

Stanford University

Status and phase: Withdrawn; Phase 2

Conditions: Eye Cancer; Retinoblastoma

Treatments: Procedure: Intra-arterial infusion of chemotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01151748

PEDSEYE0001

SU-07072009-3000 (Other Identifier)

Details and patient eligibility

About

Phase II study of selective intra-arterial infusion of chemotherapy for intraocular retinoblastoma

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients diagnosed with advanced intraocular retinoblastoma (International Retinoblastoma Classification group D or E*).
2. Patients with tumor recurrence or vitreous seeding following completion of systemic chemotherapy or previous radiation therapy.

Exclusion criteria

1. Congenital brain anomaly identified on MRI.
2. History of systemic coagulopathy.
3. Evidence of extra ocular retinoblastoma on clinical examination or neuroimaging.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)