Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee

Thammasat University

Status and phase: Completed; Phase 4

Conditions: Knee Osteoarthritis

Treatments: Drug: Hylan G-F 20; Drug: Corticosteroid

Study type: Interventional

Funder types: Other

Identifiers

NCT01874574

OrthoTU-01

Details and patient eligibility

About

Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients.

Full description

Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients up to 6 months.

Enrollment: 100 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of knee OA
• Knee pain for most days of the prior month
• Radiographic evidence consistent with knee OA
• Aged between 40 and 80 years old

Exclusion criteria

• Lumbar spondylosis
• Gross deformity of the knee
• Co-existent inflammatory or crystal arthritis
• Prior knee surgery
• Injury to the knee in the preceding 6 months
• Any intra-articular injection in the preceding 3 months
• Pregnant or Lactating
• Current infection in the affected knee
• Inability to provide informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups

Single shot Hylan G-F 20 (Synvisc)

Experimental group

Description:

Intra-articular injection of the Single shot 6 mL of Hylan G-F 20 (Synvisc)

Treatment:

Drug: Hylan G-F 20

Corticosteroid (Triamcinolone acetonide)

Active Comparator group

Description:

Intra-articular injection of 1 mL of 40 mg Triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline injected at the knee by single shot

Treatment:

Drug: Corticosteroid