Intra-Articular Dexmedetomidine: A Treatment for Chronic Knee Pain

Tanta University

Status: Enrolling

Conditions: Chronic Knee Pain

Treatments: Drug: Bupivacaine Hydrochloride; Drug: Triamcinolone Acetonide; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT06641206

36264PR843/9/24

Details and patient eligibility

About

Chronic knee osteoarthritis (KOA) is a painful condition with limited treatment options. Non-pharmacological approaches often fall short, leading to decreased quality of life. Ozone therapy, a simple and affordable treatment, has shown promise for pain relief. Dexmedetomidine (DEX), a sedative and analgesic, has been used successfully as an adjuvant to anesthesia and local anesthetics. Given its potential for pain management, exploring DEX as a treatment for KOA could offer a new and promising approach.

Enrollment: 70 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients were not assigned for surgical intervention;
• Patients were free of exclusion criteria

Exclusion criteria

• Patients were assigned for surgical intervention;
• Patients who had uncontrolled hypertension and/or diabetes mellitus;
• Patients who had uncompensated cardiac, renal, or hepatic diseases;
• Patients with coagulopathy, spinal deformity, allergy, or contraindication for the used drugs;
• Patients who refused to sign the informed consent were excluded from the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups

Group 1

Active Comparator group

Description:

A group of Patients from Tanta University suffering from Chronic painful knee osteoarthritis who didn't receive medical treatment and progressed to have chronic pain with decreased physical function and poorer quality of life.

Treatment:

Drug: Triamcinolone Acetonide

Drug: Bupivacaine Hydrochloride

Group 2

Active Comparator group

Description:

A group of Patients from Tanta University suffering from Chronic painful knee osteoarthritis who didn't receive medical treatment and progressed to have chronic pain with decreased physical function and poorer quality of life.

Treatment:

Drug: Dexmedetomidine