Intra-articular Dexmedetomidine Versus Neostigmine After Knee Arthroscopy (a Comparative Study)

Assiut University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Knee Injuries

Treatments: Drug: dexamedetomidine; Drug: neostigmine

Study type: Interventional

Funder types: Other

Identifiers

NCT03212495

dexmedetomidine vs neostigmine

Details and patient eligibility

About

Knee arthroscopy is a minimally invasive day case procedure which may be done for diagnosis, meniscectomy or debridement. Arthroscopic surgery is associated with a variable degree of postoperative pain, which is caused by an irritation of free nerve endings of the synovial tissue, anterior fat pad, and joint capsule due to surgical excision and resection

Full description

Many studies were done using different intra-articular agents as local anesthetics, opioids, ketamine and alfa2- adrenergic agonists for prevention and treatment of pain after knee surgeries.

Dexmedetomidine is a potent and highly selective alfa2-adrenoreceptor agonist. It has sedative-hypnotic, anxiolytic, analgesic, anesthetic and sympatholytic effects. Intra-articular dexmedetomidine was used in several studies to enhance postoperative analgesia after knee arthroscopy with an increased time to first analgesic request and a decreased need for postoperative analgesia Neostigmine is an anticholinesterase and also has antinociceptive effects when administered intrathecally or peripherally.

Enrollment: 100 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged above 18 years
• scheduled for elective arthroscopic knee surgery under intrathecal anaesthesia

Exclusion criteria

• Absolute or relative contraindications for intrathecal anaesthesia,
• Allergy for the studied drugs.
• Patients having history of cardiovascular, cerebrovascular, and respiratory diseases,
• Patients receiving chronic pain treatment or hypertension treated with alfa methyldopa, clonidine or beta adrenergic blockers were excluded from the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

dexmedetomidine (D group)

Active Comparator group

Description:

intraarticular administration of dexmedetomidine at the end of surgery

Treatment:

Drug: dexamedetomidine

neostigmine (N group)

Active Comparator group

Description:

intraarticular administration of neostigmine at the end of surgery.

Treatment:

Drug: neostigmine