Intra-articular Glucocorticoid Treatment of the Elbow

Region Gävleborg

Status: Completed

Conditions: Rheumatoid Arthritis

Treatments: Behavioral: immobilisation in a triangular sling

Study type: Interventional

Funder types: Other

Identifiers

NCT00972530

Dnr 2005:362

Details and patient eligibility

About

BACKGROUND: Intra-articular glucocorticoid injections are frequently used to relieve symptoms of arthritis. Postinjection rest has been shown to improve the outcome of knee joint injections, but not for wrist injections. Consequently, different joints respond differently on postinjection regimens.

OBJECTIVES: To investigate whether better treatment results might be achieved of post-injection rest following intra-articular glucocorticoid treatment for elbow synovitis.

METHODS: 90 patients with rheumatoid arthritis (RA) and elbow synovitis were treated with 20 mg intra-articular triamcinolone hexacetonide and randomised to either a 48 hour immobilisation in a triangular sling (n=46) or normal activity without restrictions (n=44). Primary endpoint was relapse of synovitis. In addition, pain, function according to a self assessment questionnaire (PREE) and range of movement were followed for six months.

Enrollment: 90 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Rheumatoid arthritis, and
• Clinical signs of elbow synovitis

Exclusion criteria

• Patients in function class 4 according to Steinbrocker as well as patients with oral glucocorticoid treatment corresponding to more than 7.5 mg prednisolone or intra-articular treatment in the joint the past three months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 2 patient groups

Activity

No Intervention group

Description:

Normal activity without restrictions

immobilisation

Active Comparator group

Description:

48 hours postinjection rest

Treatment:

Behavioral: immobilisation in a triangular sling