Intra Versus Extra-thoracic Oscillations in Chronic Obstructive Pulmonary Disease

Cairo University (CU)

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Device: Intrathoracic oscillatory quake; Device: High frequency extra thoracic oscillations vest

Study type: Interventional

Funder types: Other

Identifiers

NCT03885128

P.T.REC/012/001741

Details and patient eligibility

About

Chronic Obstructive Pulmonary Disease (COPD) is the fourth-leading cause of death. It is a progressive illness that requires life-long treatment.Promoting airway clearance (AC) using mucolytics together with airway clearance techniques (ACTs) form the basis for pulmonary therapy in COPD care.Therefore, new airway clearance modalities are required to decrease the detrimental effects of accumulated secretions in COPD.

One of the devices used in AC is the high frequency chest wall oscillation (The Vest). HFCWO involves the use of an inflatable vest/jacket that covers the chest and is attached to an air pulse-generating compressor which rapidly inflates and deflates the vest, producing oscillations to the chest wall of 5-25 Hz.

Another new airway clearance modality is oscillating positive expiratory pressure(Quake) which combines PEP therapy with high frequency oscillations.

Full description

The present study aimed to evaluate the effectiveness of the extra thoracic oscillations via high frequency chest wall oscillation vest (HFCWO) versus the intra thoracic oscillations via oscillatory positive expiratory pressure (OPEP) Quake device in COPD Group A: consists of 30 patients will be treated by high frequency chest wall oscillation vest along with their prescribed medical treatment. This program will be performed 4 times per week for 6 successive weeks.

Group B: consists of 30 patients will be treated by vibratory PEP (The Quake) along with their prescribed medical treatment. This program will be performed 4 times per week for 6 successive weeks.

Enrollment: 60 patients

Sex: Male

Ages: 45 to 72 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • All patients were diagnosed by chest physician based on the modified criteria defined in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines 2017.

  • All patients were diagnosed as COPD for at least two years.
  • All Patients must use their prescribed medications.

Exclusion criteria

• All patients that had one of the following were excluded from the study. History of osteoporosis, significant gastro-esophageal reflux, hiatus hernia. Recent acute cardiac event (6 weeks) or congestive cardiac failure. Any significant musculoskeletal disorders. Presence of active hemoptysis Presence of malignant disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Vest arm

Experimental group

Description:

high frequency chest wall oscillation vest performed 4 times per week for 6 successive weeks for 30 patients

Treatment:

Device: High frequency extra thoracic oscillations vest

Quake arm

Experimental group

Description:

Vibratory positive expiratory pressure quake performed 4 times per week for 6 successive weeks for 30 patients

Treatment:

Device: Intrathoracic oscillatory quake