Intraabdominal Hypertension and Occurrence of Microaspiration in Cirrhotics Under Mechanical Ventilation (ATOMIC)

University Hospital, Lille

Status: Enrolling

Conditions: Cirrhosis, Liver; Critical Illness

Study type: Observational

Funder types: Other

Identifiers

NCT04530760

2019-A02622-55 (Other Identifier)

2018_75

Details and patient eligibility

About

The study aims to demonstrate the relationship between intra-abdominal hypertension (IAH) and abundant microaspirations in mechanically ventilated cirrhotic.

Full description

Intra-abdominal pressure monitoring will be performed using intra-vesical pressure every 8 hour in the first 2 days of mechanical ventilation.

Micro aspiration is defined by pepsin or amylase positivity in trachea suction. Two groups will be compared : one with IAH , one without IAH.

Enrollment: 226 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients
• Cirrhosis
• intubation and mechanical ventilation

Exclusion criteria

• pregnancy
• oliguric patients
• impossibility to measure intravesical pressure

Trial design

226 participants in 2 patient groups

intraabdominal hypertension group

Description:

patients with intraabdominal hypertension defined as intravesical pressure more than 12 mmHg

control group

Description:

patients with no intraabdominal hypertension