Intraartecular Platelet Rich Plasma for Sacroiliitis

Mansoura University

Status

Completed

Conditions

Sacroiliitis

Treatments

Other: Ultrasound guided Sacroiliac intra-articular injection

Study type

Interventional

Funder types

Other

Identifiers

NCT03834480

MS17.10.03

Details and patient eligibility

About

Comparison between the effect of steroids and platelet-rich plasma on low back pain after ultrasound-guided sacroiliac injection to determine any is more effective and of long duration

Full description

A prospective randomized controlled study was conducted at the department of anesthesiology Mansoura University Hospital during the period from December 2017 to January 2019 on fifty ASA I-III adult patients, of both sex after approval of IRB (Institutional Review Board) ID number MS17.10.03 & IRB date 12-11-2017. The patients were randomly allocated into two groups each of 25 patients according to computer-generated random number codes that were placed in sealed envelopes, double blinded, with parallel-group comparison.

Steroid Group (S) (n. 25):- Patients were injected by 4 ml of sterile water containing the methylprednisolone Acetate (Depo-Medrol) per-kg calculated dose (0.5mg/kg up to a lean muscle body weight of 80kg in the painful sacroiliac joint).

Platelet rich plasma Group (P) (n. 25):-Patients received fixed volume of 4 ml platelet-rich plasma in the inflamed painful sacroiliac joint.

Enrollment

2 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Patients of either sex. 2. ASA I&III. 3. Age between 18 - 70 years. 4. Chronic lower back pain of sacroiliac origin. 5. Anatomy of the joint can identified by the ultrasonography. Exclusion criteria
2. Patients with contraindications to sacroiliac injection.
3. Patients known to be allergic to platelet rich plasma or local anesthetics.
4. History of immune suppression or immune compromised diseases
5. Patient below age of 18 as the joint will undergo normal physiological changes.
6. Patient over 70 years.
7. Sacroiliac pain of multiple sources.
8. Preoperative shivering or fever (>38oc).
9. Hepatic, renal and heart failure patients.
10. Patients on; anticoagulants, antiplatelet, and with INR≥1.5.
11. Exclude corticosteroid injection in the sacroiliac joint at the last three months.
12. Patient refusal.