Intraarticular Antibiotic in TKA

The Washington University

Status and phase: Completed; Phase 4

Conditions: Antibotics in Cementless Knees

Treatments: Device: Vancomyscin; Drug: Tobramycin Powder

Study type: Interventional

Funder types: Other

Identifiers

NCT04297631

201911147

Details and patient eligibility

About

The purpose of the study is to determine the intra-articular concentration of vancomycin and tobramycin after administration of vancomycin and tobramycin powder in primary cementless total knee arthroplasty and determine the serum concentrations of these antibiotics postoperatively.

Full description

Patients will be identified by medical record review to make sure they meet inclusion and exclusion criteria. Patients that qualify and sign consent will have tobramycin and vancomycin antibiotic powder placed into the knee during surgery. Postoperative drain fluid from the knee will be collected.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age over 18
2. Total knee arthroplasty for primary osteoarthritis. Primary diagnosis of knee osteoarthritis

Exclusion criteria

1. Diminished mental capacity
2. Vancomycin allergy
3. Tobramycin allergy
4. Chronic kidney disease stage III and stage IV

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Vancomycin Powder

Experimental group

Description:

All patients getting vancomycin to see concentration after 24hrs in knee drain and serum levels.

Treatment:

Device: Vancomyscin

Tobramycin Powder

Experimental group

Description:

All patients getting Tobramycin to see conceration after 24hrs in knee drain and serum levels.

Treatment:

Drug: Tobramycin Powder