Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

Saint Alphonsus Regional Medical Center

Status and phase: Completed; Phase 3; Phase 2

Conditions: Arthritis of Hip; Arthritis Knee

Treatments: Drug: Triamcinolone Intraarticular Injection; Drug: Ketorolac Intraarticular Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT04441112

SaintAlphonsusRMC

Details and patient eligibility

About

Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Symptomatic, radiographically proven degenerative joint disease in the hip or knee

Exclusion criteria

• recent injection in the hip or knee within the previous 3 months
• history of traumatic osteoarthritis or ligamentous reconstruction
• chronic narcotic use
• history of inflammatory or neuropathic arthropathy
• pregnant and/or nursing women
• allergy or strong reaction to study medications

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 4 patient groups

Ketorolac Intraarticular Hip Injection

Experimental group

Description:

Patients will receive an intraarticular hip injection with ketorolac.

Treatment:

Drug: Ketorolac Intraarticular Injection

Triamcinolone Intraarticular Hip Injection

Active Comparator group

Description:

Patients will receive an intraarticular hip injection with triamcinolone.

Treatment:

Drug: Triamcinolone Intraarticular Injection

Ketorolac Intraarticular Knee Injection

Experimental group

Description:

Patients will receive an intraarticular knee injection with ketorolac.

Treatment:

Drug: Ketorolac Intraarticular Injection

Triamcinolone Intraarticular Knee Injection

Active Comparator group

Description:

Patients will receive an intraarticular knee injection with triamcinolone.

Treatment:

Drug: Triamcinolone Intraarticular Injection