Intraarticular Xylitol Injections for Knee Osteoarthritis

Hadassah Medical Center

Status and phase: Unknown; Phase 4

Conditions: Knee Osteoarthritis

Treatments: Device: Xylitol

Study type: Interventional

Funder types: Other

Identifiers

NCT02104596

Xylitol- HMO-CTIL

Details and patient eligibility

About

Hypothesis: Intraarticular injections of isotonic Xylitol solution will improve pain in patients with knee osteoarthritis (OA).

Enrollment: 96 estimated patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age over 45
• Tibiofemoral osteoarthritis
• OA stage 2-3 on xray
• Pain VAS > 40mm
• No NSAIDs for 3 weeks
• No analgetics for 38 hours

Exclusion criteria

• Pain VAS > 80mm
• Pain VAS in contralateral knee > 40mm
• Inflammatory arthritis
• Severe effusion
• Posttraumatic osteoarthritis
• Unstable knee
• Isolated patellofemoral disease
• Paracetamol hypersensitivity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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96 participants in 2 patient groups, including a placebo group

Xylitol injection

Experimental group

Description:

Intraarticular injection of Xylitol

Treatment:

Device: Xylitol

Control

Placebo Comparator group