Intrabone Transplantation of Allogenic Peripheral Blood Stem Cells in Patients With Myeloid and Lymphoid Malignancies.

Maria Sklodowska-Curie National Research Institute of Oncology

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Lymphoma; Leukemia

Treatments: Procedure: Intrabone transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT01728389

IBT-COI-01

Details and patient eligibility

About

The purpose of the study is to evaluate efficacy and safety of direct intrabone transplantation procedure of peripheral blood haematopoietic stem cells form HLA-matched sibling donors in patients with myeloid and lymphoid malignancies.

Full description

Allogenic haematopoietic stem cell transplantation is an established treatment option for haematologic malignancies, especially leukaemias and lymphomas, providing curative potential. The optimal donor is HLA-matched sibling and G-CSF stimulated peripheral blood is nowadays the most common source of stem cells. Routinely used route of stem cell transplantation is intravenous infusion via central venous catheter. Based on the animal studies, only 10-15% of intravenously transplanted stem cells migrate to haematopoietic sites while the rest is lost in other organs. Results of studies of direct intrabone allogenic cord-blood cells transplantation in humans confirm that this route of transplantation is associated with less probability of graft failure and moreover may reduce risk of graft-versus-host disease and malignancy relapse. For those purposes in the current study we investigate intrabone route of allogenic peripheral blood stem cell transplantation. Our intention is to achieve fast engraftment and minimize risk of relapse and graft graft-versus-host disease.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-55 years
• Diagnosis of leukaemia or lymphoma
• Indication for allogenic stem cell transplantation according to European Group for Blood and Marrow Transplantation guidelines
• HLA-matched sibling donor qualified for peripheral blood stem cell donation
• Performance status WHO 0-1
• Written informed consent

Exclusion criteria

• Organ dysfunction: elevated ALT, AST, bilirubin, AF; creatinine >1.5 upper normal limit; LVEF <45%
• Active infection
• Unstable diabetes
• Psychiatric diseases
• Obesity or anatomical obstacle for direct intrabone transplantation

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Intrabone transplantation

Experimental group

Description:

Direct intrabone transplantation procedure of peripheral blood haematopoietic stem cells form HLA-matched sibling donors in patients with myeloid and lymphoid malignancies.

Treatment:

Procedure: Intrabone transplantation