Intracardiac T-wave Alternans and Ischemia

Columbia University

Status: Completed

Conditions: Ischemia

Treatments: Procedure: Percutaneous coronary intervention

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT00669552

AAAC6715

Details and patient eligibility

About

T-wave alternans is a test that looks at microvolt changes in the T-wave on a beat to beat basis. The presence or absence of such changes has been shown to predict or exclude future arrhythmic events. The mechanism of T-wave alternans is unclear, but may relate to calcium metabolism in the heart, and may be affected by conditions such as ischemia or heart failure.

The purpose of this study is to determine whether T-wave alternans, as measured through the lead of an implantable defibrillator, is produced by acute ischemia induced by occlusion during percutaneous coronary interventions.

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient with CAD undergoing PCI with appropriate Medtronic implantable defibrillator.

Exclusion criteria

• non-elective procedure
• non-qualifying defibrillator type.

Trial design

11 participants in 1 patient group

Medtronic defibrillator

Description:

Patients undergoing a percutaneous coronary intervention (PCI) with an implanted Medtronic defibrillator with the capability of telemetry of the intracardiac signal.

Treatment:

Procedure: Percutaneous coronary intervention