Intracellular Tight Junction Permeability in Schizophrenia: Focus on Zonulin

University of Maryland Baltimore (UMB)

Status: Completed

Conditions: Celiac Disease; Schizophrenia

Treatments: Procedure: Blood Draw

Study type: Observational

Funder types: Other

Identifiers

NCT01558570

HP-00049310

Details and patient eligibility

About

The purpose of this protocol is to collect serum zonulin levels in people with schizophrenia. This one time visit will collect zonulin levels, antibodies to gliadin (tissue transglutaminase and antigliadin antibodies) and other information that may relate to increased intracellular tight junction permeability as it related to the immune and stress system and the immune association with kynurenic acid pathway 50. Data will be collected for use in future grant applications and published reports.

Enrollment: 100 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• DSM-IV Diagnosis of Schizophrenia or Schizoaffective Disorder
• Male or females between ages of 18 to 75 years

Exclusion criteria

• Score below 10/12 on the Evaluation to Sign Consent (ESC)

Trial design

100 participants in 1 patient group

Schizophrenia

Treatment:

Procedure: Blood Draw