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Intracellular Tight Junction Permeability in Schizophrenia: Focus on Zonulin

University of Maryland Baltimore (UMB) logo

University of Maryland Baltimore (UMB)

Status

Completed

Conditions

Celiac Disease
Schizophrenia

Treatments

Procedure: Blood Draw

Study type

Observational

Funder types

Other

Identifiers

NCT01558570
HP-00049310

Details and patient eligibility

About

The purpose of this protocol is to collect serum zonulin levels in people with schizophrenia. This one time visit will collect zonulin levels, antibodies to gliadin (tissue transglutaminase and antigliadin antibodies) and other information that may relate to increased intracellular tight junction permeability as it related to the immune and stress system and the immune association with kynurenic acid pathway 50. Data will be collected for use in future grant applications and published reports.

Enrollment

100 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • DSM-IV Diagnosis of Schizophrenia or Schizoaffective Disorder
  • Male or females between ages of 18 to 75 years

Exclusion criteria

  • Score below 10/12 on the Evaluation to Sign Consent (ESC)

Trial design

100 participants in 1 patient group

Schizophrenia
Treatment:
Procedure: Blood Draw

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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