Intracranial Pressure During Migraine (MigICP)

University Hospital, Clermont-Ferrand

Status: Unknown

Conditions: Menstrual Migraine

Treatments: Other: Intracranial pressure variations

Study type: Observational

Funder types: Other

Identifiers

NCT03152305

2014-A00042-45 (Other Identifier)

CHU-331

Details and patient eligibility

About

An increase in intracranial pressure (ICP) during migraine attacks is possible and could contribute to pain initiation and maintenance. From now on, it was not possible to measure ICP in a non-invasive way. The development of a new tool allows non-invasive self-measures of ICP variations. Thus, it is possible for the first time to look for such ICP variations during migraine attacks and to conclude if this mechanism is implied in the pathophysiology of migraine.

Full description

Womens presenting with regular menstrual migraine treated with triptans will be included in the study. Self-measure of ICP will be performed outside and during menstrual migraine attacks. The potential variations will be compared to the measures done on matched healthy women outside and during menses.

Enrollment: 60 estimated patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 50 non menopausal women
• Menstrual migraine
• Using a triptan as usual treatment to relieve attacks
• Usual triptan efficacy although recurrence is possible

Exclusion criteria

• Disease of the ear
• Intracranial hypertension
• Chronic daily headache
• Use of topiramate or acetazolamide
• Triptans used more than 10 days/month
• Analgesic drug used more than 15 days/month
• Uncontrolled high blood pressure
• BMI >30
• Ongoing allergic rhinitis or flu

Trial design

60 participants in 2 patient groups

Women with menstrual migraine

Description:

Womens presenting with regular menstrual migraine treated with triptans will be included in the study.

Treatment:

Other: Intracranial pressure variations

Matched control

Description:

The potential variations will be compared to the measures done on matched healthy women outside and during menses.

Treatment:

Other: Intracranial pressure variations