Intradialytic Exercise on the Fatigue, Sleep Disorder, Arterial Stiffness and Endothelial Function in Uremic Patients

Buddhist Tzu Chi General Hospital

Status: Completed

Conditions: Hemolysis; Adipocytes; Sleep Disorder; Fatigue; Exercise

Treatments: Other: Cycling exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT04098848

IRB106-139-A

Details and patient eligibility

About

To determine the effect of intradialytic cycling exercise on fatigability, sleep disorders, arterial stiffness and endothelial function in dialysis patients

Full description

The endothelium is a key regulator of vascular homeostasis and chronic exposure to vascular risk factors alters the regulatory properties of the endothelium, which progresses toward a pro-inflammatory pattern, senescence, and apoptosis. Endothelial cell integrity and function are critical to the prevention of atherosclerosis, and therefore endothelial cell injury and dysfunction are major steps in the development and progression of cardiovascular disease. Endothelial dysfunction may be the landmark of active disease process through the course of atherosclerotic cardiovascular disease, and a significant risk factor for future cardiovascular events.

Several studies had reported that not only medical treatment but also exercise could improve physical and vascular functions, dialytic efficiency, quality of sleep, fatigue and depression et al. Exercise could be classified to aerobic, Anaerobic exercise and resistance et. Several studies have shown that regular cycling exercise in hemodialysis patients could improve physical activity, sleep quality, and reduce fatigability. Therefore, exercise plays an important role in hemodialysis patients. According to these benefits, the investigator's study was designed to explore the effects of intradialytic cycling exercise on sleep quality and fatigability, adipokines and myokinins levels in hemodialysis patients.

Enrollment: 114 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Regular hemodialysis more than 3 months with 4 hours a time, thrice a week
• Eligible to sign permit

Exclusion criteria

• Could not sign permit or do not want to join the trial
• Infection
• Amputation of any one of the lower limb
• Hemodynamic unstable
• Acute myocardial infarction (AMI) in recent 6 months
• Unstable heart condition, such as unstable angina, arrythmia
• Deep vein thrombosis (DVT)
• History of kidney transplantation
• Vascular access over lower limb

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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114 participants in 2 patient groups

Intradialytic exercise

Experimental group

Description:

Cycling exercise 30 minutes a time, three times a week during hemodialysis

Treatment:

Other: Cycling exercise

Control group

No Intervention group

Description:

not participate in cycling exercise during hemodialysis