Intralesional Injection Of Methotrexate Versus Triamcinolone Acetonid In Treatment Of Localized Psoriasis

Sohag University

Status: Enrolling

Conditions: Localized Psoriasis

Treatments: Drug: Intralesional Injection of Methotrexate; Drug: Triamcinolone Acetonid

Study type: Interventional

Funder types: Other

Identifiers

NCT05408208

soh-med-22-05-04

Details and patient eligibility

About

The aim of the present study is to evaluate the efficacy of intralesional injection of methotrexate in comparison with Intralesional Injection of Triamcinolone Acetonid in localized psoriasis (body surface area < 10%) .

Full description

study enrolling 30 patients of localized psoriasis. 15 patients received intralesional methotrexate :

• Taking aseptic condition ,One psoriatic plaque will treated with Intralesional injection of methotrexate (25mg /ml) at dosage of 0.1 ml /cm2.
• Another plaque will treated with intralesional ingection of distilled water as controlled plaque.
• patient will receive oral folic acid 5mg tablet every day except the day of injection.

Other 15 patients received intralesional trimethinolone acetonide:

• Taking aseptic condition , One plaque will treated with Intralesional injection of trimethinolone acetonide (10mg/ml) at dosage of 0.1 ml/ cm2 .
• another plaque will treated with Intralesional injection of distilled water as controed plaque.
• Patients will take 6 sessions every 2 weeks for 3 months and will followed up at 2 month and 3 months after treatment .

Enrollment: 30 estimated patients

Sex: All

Ages: 15 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with localized Psoriasis (body surface area<10%)

Exclusion criteria

• Patient refusal. Generalized psoriasis. Pregnancy. Lactation. Immunocompromised patients . Patients with history of hypersensitivity to methotrexate. Patients with other inflammatory skin disorders. Patients with chronic hepatic, renal , pulmonary ,or haematological disorders. patients on treatment for psoriasis .

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Methotrexate

Active Comparator group

Description:

Intralesional injection of methotrexate

Treatment:

Drug: Intralesional Injection of Methotrexate

Drug: Triamcinolone Acetonid

Triamcinolone Acetonid

Active Comparator group

Description:

Intralesional injection of trimethinolone acetonide

Treatment:

Drug: Intralesional Injection of Methotrexate

Drug: Triamcinolone Acetonid