Intralesional Vitamin D Injection for Treatment of Common Warts

Stephen P. Merry

Status and phase: Completed; Phase 2

Conditions: Warts

Treatments: Drug: Placebo; Drug: Vitamin D3

Study type: Interventional

Funder types: Other

Identifiers

NCT04278573

19-010219

Details and patient eligibility

About

Researchers are trying to find out if injecting Vitamin D into a wart is an effective treatment.

Enrollment: 77 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients seen at the Mayo Clinic Rochester practices
• Patients suffering from one or more cutaneous warts as diagnosed by the examining physician at baseline visit on typical diagnostic characteristics
• Able to provide consent
• Both recalcitrant and non-recalcitrant warts will be included

Exclusion criteria

• Patients with prior use of home or office-based destructive treatments for this wart(s) in the last 1 month with salicylic acid (SA) or cryotherapy
• Immunoadjuvant therapy for warts in the last 4 months (e.g Candida)
• History of vitamin D injection of warts ever
• High-dose vitamin D supplementation (>4,000 IU daily or equivalent) in the preceding 3 months
• Pregnancy or lactation
• Facial or genital warts
• Lesions not felt by the examining clinician to be a wart (e.g., corns or calluses)
• Immunosuppression (to include immunosuppressive medications or conditions as judged by the physician evaluating the patient at the baseline visit).
• Allergy to sesame oil

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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77 participants in 2 patient groups, including a placebo group

Vitamin D3 Treatment Group

Experimental group

Description:

Subjects will receive a Vitamin D3 injection into their wart

Treatment:

Drug: Vitamin D3

Placebo Group

Placebo Comparator group

Description:

Subjects will receive a placebo injection into their wart

Treatment:

Drug: Placebo