Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial

Aula Dental Avanzada

Status: Enrolling

Conditions: Dental Pain; Local Anesthesia; Inferior Alveolar Nerve Block Failure; Symptomatic Irreversible Pulpitis (SIP)

Treatments: Procedure: Inferior Alveolar Nerve Block; Procedure: Intraligamentary Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT07130760

ILA VS AINB PULP

Details and patient eligibility

About

This multicenter randomized trial compares the clinical effectiveness of intraligamentary injection versus inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular molars. The goal is to determine which technique provides better pain control during endodontic treatment.

Full description

Symptomatic irreversible pulpitis in mandibular molars presents a clinical challenge due to the difficulty in achieving profound anesthesia. This prospective, randomized, controlled clinical trial evaluates two anesthetic techniques-intraligamentary injection (ILA) versus inferior alveolar nerve block (IANB)-to compare their efficacy in eliminating pain during endodontic access. Patients will be enrolled from multiple dental centers following standardized inclusion and exclusion criteria. Pain will be assessed using validated scales. Statistical analysis will be conducted to determine significant differences in anesthetic success between groups.

Enrollment: 52 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged 18 years or older
• Presenting with symptomatic irreversible pulpitis in a mandibular molar
• Vital response to cold testing
• Ability to understand and provide informed consent
• Available for follow-up and data collection

Exclusion criteria

• Known allergy to lidocaine or epinephrine
• Pregnancy or breastfeeding
• Use of analgesics or anti-inflammatory drugs in the previous 6 hours
• Non-vital or previously treated teeth
• Significant systemic disease (ASA III or above)
• History of psychiatric or neurological disorders affecting pain perception

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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52 participants in 2 patient groups

Intraligamentary Injection Group

Experimental group

Description:

Patients in this arm will receive intraligamentary anesthesia prior to endodontic access.

Treatment:

Procedure: Intraligamentary Injection

Inferior Alveolar Nerve Block Group

Active Comparator group

Description:

Patients in this arm will receive standard inferior alveolar nerve block prior to endodontic access.

Treatment:

Procedure: Inferior Alveolar Nerve Block