Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortion

Ahmed Mohamed Bahaa Eldin Ahmed

Status and phase: Unknown; Phase 1

Conditions: Recurrent Miscarriage

Treatments: Drug: Intralipid

Study type: Interventional

Funder types: Other

Identifiers

NCT03132779

Intralipid

Details and patient eligibility

About

Evaluating the effect of intralipid on the natural killer cells

Full description

This study will done on women with recurrent spontaneous abortions having increased NKCELLS activity and evaluate the effect of Intralipid on them after re-estimation of NKcells activity again after one week of Intralipid adminstration

Enrollment: 34 estimated patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All women icluded having recurrent spontaneous abortions equal or more than twice.
• Alittle women having increased NKCELLS activity.

Exclusion criteria

• Any other diseases causing miscarriage as autoimmune (lupus erythematosus or antiphospholipid antibodies syndrome )or endocrinopathy (diabetes mellitus, thyroid disorders and hyperprolactinaemia)or thrombophilia (factor v leiden mutation, protein c or s deficiency, prothrombin G20210A mutation, antithrombin III deficiency ) or abnormal karyotyping to one or both of parents or previous history of hormonal contraception or intrauterine device usage at last 3 months or any contraindications for intralipid usage.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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34 participants in 1 patient group

One armed

Experimental group

Description:

One group of patient will take Intralipid for all

Treatment:

Drug: Intralipid