Intranasal LAIV Mucosal Immunity Examination
Status and phase
Conditions
Treatments
Details and patient eligibility
About
The research of the investigators is focused on the understanding how the immune system functions and responds to intranasal vaccines. Intranasal vaccines do not lead to the same changes in the blood that intramuscular vaccines do. Therefore, the investigators want to look at the function of immune (lymphoid) organs that are near the nose. The closest immune organs are the adenoids and tonsils. Mice do not have tonsils allowing for the investigators to answer these questions. Human lymphoid tissue will allow the investigators to better understand the molecular behavior of these cells in humans.
The purpose of this protocol is to administer the FDA approved live attenuated influenza vaccine or no vaccine to patients undergoing adenoidectomy and/or tonsillectomy for obstructive sleep apnea prior to surgery and then collect the tissue (adenoid and/or tonsil tissue) that would normally be discarded from surgery. This will allow for improved understanding of what happens after vaccination.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Patient undergoing tonsillectomy and adenoidectomy as part of the standard of care for sleep apnea
Exclusion criteria
- Chronic Tonsillitis
- Immune Deficiency
- Already received this year's flu vaccine
Trial design
Primary purpose
Allocation
Interventional model
Masking
25 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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