Intraocular Pressure and Optic Nerve Sheath Diameter Changes at Different PEEP Levels

Marmara University

Status: Terminated

Conditions: Intracranial Pressure; Intraocular Pressure; Positive End-expiratory Pressure

Treatments: Other: Positive end-expiratory pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT03938402

09.2019.378

Details and patient eligibility

About

Positive end-expiratory pressure (PEEP) is sometimes used during perioperative period, as it has favourable effects on lung mechanics. Unfortunately, it has some negative effects on the patients, like increased intraabdominal, intrathoracic, intracranial and intraocular pressures. In this study the investigators aimed to investigate the effects of different PEEP levels on the patients' intraocular and intracranial pressures. Intraocular pressure will be measured by ocular tonometry, and intracranial pressure will be estimated by optic nerve sheath diameter measurement. The measurements will be performed in the operating room in the patients undergoing laparotomic surgery.

Enrollment: 15 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing laparotomy for gastrointestinal surgery
• American Society of Anesthesiologists (ASA) 1 or 2 physical status
• Elective surgery

Exclusion criteria

• Patients with glaucoma
• ASA 3 or over physical status
• Emergency surgery

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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15 participants in 3 patient groups

PEEP 5

Experimental group

Treatment:

Other: Positive end-expiratory pressure

PEEP 10

Experimental group

Treatment:

Other: Positive end-expiratory pressure

PEEP 15

Experimental group

Treatment:

Other: Positive end-expiratory pressure