Intraocular Pressure Change Following Intravitreal Injection of Anti-vascular Endothelial Growth Factor Agent

Prince of Songkla University

Status: Completed

Conditions: Intraocular Pressure

Treatments: Drug: Intravitreal injection (bevacizumab or ranibizumab)

Study type: Observational

Funder types: Other

Identifiers

NCT02474225

EC-56-168-02-4-2

Details and patient eligibility

About

The introduction of additional fluid into the vitreous cavity by intravitreal therapy would be expected to cause an immediate rise in the intraocular pressure. This transient, short-term intraocular pressure elevation (lasting up to 30 minutes) after intravitreal anti-vascular endothelial growth factor therapy has been well describe. The investigators aim to study the prevalence of the sustained intraocular pressure elevation associated with intravitreal injection of anti-vascular endothelial growth factor agents.

Full description

Intravitreal injections of anti-vascular endothelial growth factor agents are commonly used to treat a variety of retinal and choroidal neovascular diseases. The introduction of additional fluid into the vitreous cavity by intravitreal therapy would be expected to cause an immediate rise in the intraocular pressure.

Although there is one study showed no significant changes in the intraocular pressure many retrospective studies showed the impacts on the intraocular pressure elevation. The investigators aim to prospective evaluate the intraocular pressure change in non-glaucomatous patients receiving an intravitreal anti-vascular endothelial growth factor therapy.

Enrollment: 70 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled to receive intravitreal injection of anti-vascular endothelial growth factor agent (either bevacizumab or ranibizumab), and
• Age of 18-85 year-old, and
• Initial intraocular pressure < 21 mmHg

Exclusion criteria

• Diagnosis of open angle, or
• Diagnosis of angle-closure glaucoma, or
• Diagnosis of glaucoma suspect (intraocular pressure > 21 mmHg on 2-consecutive visit and/or cup to disc ratio > 0.5) , or
• Currently receive systemic beta-blocker
• Previously received intravitreal injection of anti-vascular endothelial growth factor agent
• Previously received intravitreal injection of steroid or gancyclovir
• Current use of steroid eye drop
• Any ocular surface disease preclude a reliable intraocular pressure measurement