Intraocular Pressure Changes Associated With Tracheal Extubation: Comparison of Sugammadex With Conventional Reversal of Neuromuscular Blockade

T.C. ORDU ÜNİVERSİTESİ

Status and phase: Completed; Phase 4

Conditions: Intraocular Pressure Changes During Tracheal Extubation

Treatments: Drug: neostigmine+atropine; Drug: sugammadex

Study type: Interventional

Funder types: Other

Identifiers

NCT02215382

Odu-3

Details and patient eligibility

About

The aim of this study, comparison of effects of sugammadex versus neostigmine/atropine combination on hemodynamic parameters and intraocular pressure during tracheal extubation.

This prospective, randomised study was designed to compare two reversal methods with respect to changes in IOP, heart rate and blood pressure during tracheal extubation period.

Enrollment: 36 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II physical status
• elective surgery
• endotracheal intubation under general anesthesia

Exclusion criteria

• emergency surgery
• pregnancy
• laparoscopic surgery
• prone position
• BMI > 30 kg/m2
• sedative drug use in last month
• patients with glaucoma.
• ASA > II physical status

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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36 participants in 2 patient groups

sugammadex

Active Comparator group

Treatment:

Drug: sugammadex

neostigmine + atropine

Active Comparator group

Treatment:

Drug: neostigmine+atropine