Intraoperative Bleeding During Endoscopic Sinus Surgery

The University of Chicago

Status: Completed

Conditions: Blood Loss

Treatments: Drug: propofol; Drug: sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01014728

09-317A

Details and patient eligibility

About

The purpose of this study is to compare the blood loss during sinus surgery looking at two different types of anesthesia: either intravenous anesthesia with propofol or inhalational anesthesia with sevoflurane.

Enrollment: 33 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male or female patients who are 18 years of age or older,
• ASA grade 1 (normal otherwise healthy patient),
• ASA grade 2 (patient with mild systemic disease),
• patients who have chronic sinusitis with or without nasal polyps.

Exclusion criteria

• pregnancy,
• abnormal coagulation panel
• preoperative use of NSAIDS or ASA medications within 7 days,
• end-stage renal disease,
• allergy to any of the used medications,
• maximal body mass index over 35

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

33 participants in 2 patient groups

Intravenous anesthesia

Active Comparator group

Description:

Intravenous anesthesia with propofol for endoscopic sinus surgery

Treatment:

Drug: propofol

Inhalation anesthesia

Active Comparator group

Description:

Inhalation anesthesia with sevoflurane for endoscopic sinus surgery

Treatment:

Drug: sevoflurane