Intraoperative Brain Microdialysis to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection.

Mayo Clinic

Status: Invitation-only

Conditions: Epilepsy

Treatments: Procedure: Intraoperative brain microdialysis

Study type: Interventional

Funder types: Other

Identifiers

NCT04531722

19-000398

Details and patient eligibility

About

This research study will investigate the fluid from the area of the brain that is being removed during clinical epilepsy surgery. The goal is to analyze this fluid for inflammatory markers that can potentially help identify new strategies in the future to control seizures in individuals with epilepsy who fail to respond to currently available drugs.

Enrollment: 3 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Failure to respond to at least two trials of anti-seizure drugs with different mechanisms of action
• Normal MRI

Exclusion Criteria

• Active immunomodulatory therapy
• Autoimmune disorder
• Signs or symptoms consistent with comorbid infection
• Oncological comorbidity

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

3 participants in 1 patient group

drug-resistant temporal lobe epilepsy

Experimental group

Description:

Our current standard practice is to use a lateral approach through the middle temporal gyrus to place 3 depth electrodes targeting the hippocampus for intraoperative verification of pathological epileptiform activity prior to resection. Our research protocol will add one FDA approved electrode that has a central cannula for insertion of a microdialysis probe. The electro-physiological data that will be gathered is not altered and this methodology will not impact standard clinical care, except and will not to extend the duration in the OR - the measurements will occur during the clinical electrocorticography (ECoG; intracranial electroencephalography (iEEG)) procedure by 15 min.

Treatment:

Procedure: Intraoperative brain microdialysis