Intraoperative Different Concentrations Oxygen And Oxidatıve Stress Markers

Zonguldak Bulent Ecevit University

Status: Completed

Conditions: Hyperoxia; Stress

Treatments: Procedure: taking arterial blood sample through the injector

Study type: Interventional

Funder types: Other

Identifiers

NCT05099523

2021/01

Details and patient eligibility

About

The aim of the study was to assess the effect of intraoperative oxygen (O2), which was applied at 30% and 50% concentrations on patients who had undergone septoplasty surgery, on Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI).

Enrollment: 40 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients aged between 18-60 years,
• ASA I-II risk class with a minimum operative time of 1.5 hour(s) for whom septoplasty operation under elective conditions

Exclusion criteria

• metabolic, endocrine, hepatic, cardiac, or renal diseases,
• malignancies and who used a drug with antioxidant properties such as vitamin E-C
• acetylcysteine in the last 48 hours,
• patients requiring intraoperative 100% O2 inhalation

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups, including a placebo group

group I

Placebo Comparator group

Description:

50%Fio2

Treatment:

Procedure: taking arterial blood sample through the injector

group II

Active Comparator group

Description:

30%Fio2

Treatment:

Procedure: taking arterial blood sample through the injector