Intraoperative EEG Monitoring and Postoperative Delirium in Elderly Patients With Sevoflurane Anesthesia

The First Affiliated Hospital of Anhui Medical University

Status

Completed

Conditions

Electroencephalogram

Sevoflurane

Postoperative Delirium

Treatments

Drug: Low MAC

Drug: High MAC

Study type

Interventional

Funder types

Other

Identifiers

NCT04292561

201912

Details and patient eligibility

About

Delirium is an acute onset of attentional and cognitive impairment. BIS guided anesthesia can reduce the incidence of postoperative delirium. Long term electroencephalogram (EEG) suppression during operation is related to postoperative delirium. The latest research shows that the anesthesia depth guided by EEG does not reduce the incidence of postoperative delirium. The purpose of this study was to explore the relationship between anesthesia exposure with different minimum alveolar concentration(MAC) and postoperative delirium(POD), and to observe the characteristics of EEG.

Full description

More and more studies have focused on the relationship between EEG inhibition and postoperative delirium in general anesthesia. At present, there are two kinds of commonly processed quantitative EEG monitoring to evaluate the depth of anesthesia, one is bispectral index (BIS) and the other is patient state index (PSI). The relationship between intraoperative anesthetic exposure and postoperative delirium is unclear, or whether potential patient characteristics increase the risk of EEG suppression and postoperative delirium.

Gastrointestinal surgery can lead to long-term changes in colonic flora, which can remotely regulate brain function through the gut brain axis. We speculated that the abnormal composition of intestinal flora before abdominal operation might be the influencing factor of POD.

Enrollment

460 patients

Sex

All

Ages

60 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of gastrointestinal diseases
Patients were aged 60 to 90 years
American Society of Anesthesiologists (ASA) risk classification II-IV
Patients were scheduled to undergo elective major abdominal operation(with a anticipated time of 2-6 h)

Exclusion criteria

Preoperative dementia or cognitive impairment
Mental instability or mental illness
Patients with any factors affecting cognitive assessment, such as language, vision and hearing impairment
Any cerebrovascular accident occurred within 3 months, such as stroke etc
Previous history of delirium
Known hypersensitivity to sevoflurane or history of malignant hyperthermia
Abuse of narcotic sedative and analgesic drugs
Those who have reoperation within 7 days after operation